ARG45376
anti-SIGIRR antibody [10D5]
anti-SIGIRR antibody [10D5] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [10D5] recognizes SIGIRR |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 10D5 |
| 同位型 | IgG2 |
| 靶点名称 | SIGIRR |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to extracellular domain of human SIGIRR. |
| 偶联标记 | Un-conjugated |
| 別名 | SIGIRR; Single Ig And TIR Domain Containing; TIR8; Toll/Interleukin-1 Receptor 8; IL-1R8; Single Immunoglobulin And Toll-Interleukin 1 Receptor (TIR) Domain; Single Immunoglobulin Domain-Containing IL1R-Related Protein; Single Immunoglobulin Domain IL1R1 Related; Single Ig IL-1R-Related Molecule; Single Ig IL-1-Related Receptor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G chromatography |
| 缓冲液 | PBS |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SIGIRR |
| 全名 | Single Ig And TIR Domain Containing |
| 背景介绍 | Involved in negative regulation of Toll signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Nov 2024] |
| 生物功能 | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
| 细胞定位 | Membrane. [UniProt] |
| 预测分子量 | 46 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein; Phosphoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45376 anti-SIGIRR antibody [10D5] IHC-P image
Immunohistochemistry: Human placenta stained with ARG45376 anti-SIGIRR antibody [10D5].
