ARG55762

Name: anti-SHP2 antibody
Brand: arigo Biolaboratories
SKU: ARG55762
Price: 399 USD
Availability: InStock
Rating: 5.0 (1 reviews)

anti-SHP2 antibody

Datasheet

订购信息

包装

价格 (USD)

100 μl

399
350

50 μl

279
246

arigo in CHINA:
恩瑞科生物
☎ 400-886-0853,
0571-8708-1890

概述

产品描述	Rabbit Polyclonal antibody recognizes SHP2
反应物种	Hu
预测物种	Ms, Rat, Chk
应用	FACS, IHC-P, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	SHP2
抗原物种	Human
抗原	KLH-conjugated synthetic peptide corresponding to aa. 526-551 of Human SHP2.
偶联标记	Un-conjugated
別名	BPTP3; SHP-2; Protein-tyrosine phosphatase 2C; METCDS; PTP2C; Tyrosine-protein phosphatase non-receptor type 11; PTP-1D; CFC; PTP-2C; JMML; Shp2; Protein-tyrosine phosphatase 1D; NS1; EC 3.1.3.48; SH-PTP2; SH-PTP3; SHP2

应用说明

应用建议

应用	推荐稀释比
FACS	1:10 - 1:50
IHC-P	1:50 - 1:100
WB	1:1000

应用说明

* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Purification with Protein A and immunogen peptide.
缓冲液	PBS and 0.09% (W/V) Sodium azide.
抗菌剂	0.09% (W/V) Sodium azide.
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 5781 Human PTPN11 Swiss-port # Q06124 Human Tyrosine-protein phosphatase non-receptor type 11
基因名称	PTPN11
全名	protein tyrosine phosphatase, non-receptor type 11
背景介绍	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
生物功能	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. [UniProt]
细胞定位	Cytoplasm.
产品亮点	Related products: SHP2 antibodies; Anti-Rabbit IgG secondary antibodies; Related news: Tools for studying H. pylori diseases
预测分子量	68 kDa
翻译后修饰	Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.

检测图片 (3) Click the Picture to Zoom In

ARG55762 anti-SHP2 antibody WB image

Western blot: 30 µg of HCT116 and A549 cell lysates stained with ARG55762 anti-SHP2 antibody at 1:1000 dilution.
ARG55762 anti-SHP2 antibody IHC-P image

Immunohistochemistry: Formalin-fixed and paraffin-embedded Human hepatocarcinoma stained with ARG55762 anti-SHP2 antibody.
ARG55762 anti-SHP2 antibody FACS image

Flow Cytometry: 293 cells stained with ARG55762 anti-SHP2 antibody (bottom histogram) or without primary antibody control (top histogram), followed by incubation with FITC labelled secondary antibody.