ARG24122
anti-SHANK2 (pan) antibody [N23b/49]
anti-SHANK2 (pan) antibody [N23b/49] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [N23b/49] recognizes SHANK2 (pan) |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 特异性 | ~160kDa. Recognizes Shank1, 2 and 3. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | N23b/49 |
| 同位型 | IgG1 |
| 靶点名称 | SHANK2 (pan) |
| 抗原物种 | Rat |
| 抗原 | Fusion protein amino acids of rat Shank2 |
| 偶联标记 | Un-conjugated |
| 別名 | SHANK2; SH3 And Multiple Ankyrin Repeat Domains 2; CTTNBP1; SPANK-3; CORTBP1; SHANK; SH3 And Multiple Ankyrin Repeat Domains Protein 2; Cortactin-Binding Protein 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SHANK2 |
| 全名 | SH3 And Multiple Ankyrin Repeat Domains 2 |
| 背景介绍 | This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. |
| 生物功能 | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| 细胞定位 | Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse |
| 翻译后修饰 | Glycoprotein, Phosphoprotein |
检测图片 (2) Click the Picture to Zoom In
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ARG24122 anti-SHANK2 (pan) antibody [N23b/49] ICC/IF image
Immunofluorescence: SK-N-BE stained with ARG24122 anti-SHANK2 (pan) antibody [N23b/49] at 1:100 dilution.
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ARG24122 anti-SHANK2 (pan) antibody [N23b/49] WB image
Western blot: Rat brain stained with ARG24122 anti-SHANK2 (pan) antibody [N23b/49] at 1:1000 dilution.
