ARG24124
anti-SHANK1 antibody [N22/21]
anti-SHANK1 antibody [N22/21] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [N22/21] recognizes SHANK1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 特异性 | 190-220 kDa (alternative splice variants). No cross-reactivity against Shank2 or Shank3. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | N22/21 |
| 同位型 | IgG1 |
| 靶点名称 | SHANK1 |
| 抗原物种 | Rat |
| 抗原 | Fusion protein amino acids 469-691 of Rat Shank1 |
| 偶联标记 | Un-conjugated |
| Protein Full name | SH3 and multiple ankyrin repeat domains protein 1 |
| 別名 | SHANK1; SH3 And Multiple Ankyrin Repeat Domains 1; SSTRIP; Somatostatin Receptor-Interacting Protein; SPANK-1; SH3 And Multiple Ankyrin Repeat Domains Protein 1; SSTR-Interacting Protein; Synamon; SYNAMON; Shank1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 50% Glycerol and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SHANK1 |
| 全名 | SH3 And Multiple Ankyrin Repeat Domains 1 |
| 背景介绍 | This gene encodes a member of the SHANK (SH3 domain and ankyrin repeat containing) family of proteins. Members of this family act as scaffold proteins that are required for the development and function of neuronal synapses. Deletions in this gene may be associated with autism spectrum disorder in males. |
| 生物功能 | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| 细胞定位 | Cytoplasm, Synapse |
| 预测分子量 | 224 kDa |
| 翻译后修饰 | Methylation, Phosphoprotein |
检测图片 (3) Click the Picture to Zoom In
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ARG24124 anti-SHANK1 antibody [N22/21] IHC-P image
Immunohistochemistry: Mouse Backskin stained with ARG24124 anti-SHANK1 antibody [N22/21] at 1:100 dilution.
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ARG24124 anti-SHANK1 antibody [N22/21] ICC/IF image
Immunofluorescence: SH-SY5Y stained with ARG24124 anti-SHANK1 antibody [N22/21] at 1:50 dilution.
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ARG24124 anti-SHANK1 antibody [N22/21] WB image
Western blot: Rat brain stained with ARG24124 anti-SHANK1 antibody [N22/21] at 1:1000 dilution.
