ARG55782
anti-SH2D1A / SAP antibody
anti-SH2D1A / SAP antibody for ICC/IF,Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SH2D1A |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SH2D1A / SAP |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human SH2D1A |
| 偶联标记 | Un-conjugated |
| 別名 | SLAM-associated protein; T-cell signal transduction molecule SAP; IMD5; EBVS; Duncan disease SH2-protein; Signaling lymphocytic activation molecule-associated protein; SAP/SH2D1A; DSHP; SH2 domain-containing protein 1A; MTCP1; XLPD; LYP; XLPD1; SAP; XLP |
应用说明
| 预测反应性说明 | Mouse, Rat | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Jurkat | ||||||
| 实际分子量 | 17 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SH2D1A |
| 全名 | SH2 domain containing 1A |
| 背景介绍 | This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. [UniProt] |
| 预测分子量 | 14 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG55782 anti-SH2D1A / SAP antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG55782 anti-SH2D1A / SAP antibody.
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ARG55782 anti-SH2D1A / SAP antibody WB image
Western blot: Jurkat cell lysate stained with ARG55782 anti-SH2D1A / SAP antibody.
