ARG46468
anti-SGSM2 antibody
anti-SGSM2 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SGSM2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SGSM2 |
| 抗原物种 | Human |
| 抗原 | A 18 amino acid synthetic peptide within the last 50 amino acids of human SGSM2. |
| 偶联标记 | Un-conjugated |
| 別名 | SGSM2; RUTBC1; KIAA0397; RUTBC1; Small G protein signaling modulator 2; RUN and TBC1 domain-containing protein 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -518°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O43147 Human Small G protein signaling modulator 2 Swiss-port # Q80U12 Mouse Small G protein signaling modulator 2 |
|---|---|
| 基因名称 | SGSM2 |
| 全名 | small G protein signaling modulator 2 |
| 背景介绍 | The protein encoded by this gene is a GTPase activator with activity towards RAB32 and RAB33B, which are regulators of membrane trafficking. The encoded protein inactivates RAB32 and can bind RAB9A-GTP, a protein required for RAB32 activation. [provided by RefSeq, Oct 2016] |
| 生物功能 | Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PubMed:21808068, PubMed:26620560). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PubMed:26620560). [UniProt] |
| 细胞定位 | Cytoplasm. [UniProt] |
| 预测分子量 | 113 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
