ARG45271
anti-SGO2 antibody
anti-SGO2 antibody for Flow cytometry,ICC/IF,Western blot and Human
概述
| 产品描述 | Polyclonal antibody recognizes SGO2 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SGO2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human SGO2. |
| 偶联标记 | Un-conjugated |
| 別名 | SGO2; Shugoshin 2; TRIPIN; SGOL2; Shugoshin-Like 2; FLJ25211; Shugoshin-Like 2 (S. Pombe); Shugoshin-2; Tripin |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 180 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SGO2 |
| 全名 | Shugoshin 2 |
| 背景介绍 | Predicted to be involved in meiotic sister chromatid cohesion. Predicted to act upstream of or within several processes, including meiotic nuclear division; meiotic sister chromatid cohesion; and positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric. Located in chromosome, centromeric region and nuclear body. Part of mitotic cohesin complex. [provided by Alliance of Genome Resources, Nov 2024] |
| 生物功能 | Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation . [UniProt] |
| 细胞定位 | Cellular component; Centromere; Chromosome; Kinetochore; Nucleus. [UniProt] |
| 预测分子量 | 145 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG45271 anti-SGO2 antibody ICC/IF image
Immunofluorescence: U20S stained with ARG45271 anti-SGO2 antibody at 5 ug/ml dilution.
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ARG45271 anti-SGO2 antibody WB image
Western blot: A549, PC-3 and MOLT-4 stained with ARG45271 anti-SGO2 antibody at 0.5 μg/ml dilution.
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ARG45271 anti-SGO2 antibody FACS image
Flow Cytometry: CACO-2 stained with ARG45271 anti-SGO2 antibody at 1 µg/10^6 cells dilution.
