概述

产品描述	Rabbit Polyclonal antibody recognizes SFRP1
反应物种	Hu
应用	IHC-P, WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	SFRP1
抗原物种	Human
抗原	Synthetic peptide of Human SFRP1.
偶联标记	Un-conjugated
別名	FRP-1; FRP1; Secreted apoptosis-related protein 2; FrzA; Secreted frizzled-related protein 1; SARP2; SARP-2; FRP; sFRP-1

应用说明

应用建议	应用 推荐稀释比 IHC-P 1:50 - 1:200 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	A375
实际分子量	~ 37 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 6422 Human SFRP1 Swiss-port # Q8N474 Human Secreted frizzled-related protein 1
基因名称	SFRP1
全名	secreted frizzled-related protein 1
背景介绍	This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
生物功能	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. [UniProt]
细胞定位	Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding. [UniProt]
预测分子量	35 kDa

检测图片 (1) Click the Picture to Zoom In