ARG63243
anti-SETMAR antibody
anti-SETMAR antibody for Western blot and Human
Gene Regulation antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes SETMAR |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Cow |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SETMAR |
| 抗原物种 | Human |
| 抗原 | RWQKCVDCNGSYFD |
| 偶联标记 | Un-conjugated |
| 別名 | HsMar1; SET domain and mariner transposase fusion protein; EC 3.1.-.-; EC 2.1.1.43; Mar1; METNASE; Histone-lysine N-methyltransferase SETMAR; Metnase |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q53H47 Human Histone-lysine N-methyltransferase SETMAR |
|---|---|
| 背景介绍 | This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 78 kDa |
| 翻译后修饰 | Methylated. Methylation regulates activity in DNA decatenation. Phosphorylated at Ser-508 by CHEK1 and dephosphorylated by protein phosphatase 2A/PP2A. Phosphorylation at Ser-508 is enhanced by DNA damage and promotes recruitment to damaged DNA. It stimulates DNA repair and impairs replication fork restart. |
检测图片 (1) Click the Picture to Zoom In
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ARG63243 anti-SETMAR antibody WB image
Western Blot: Daudi lysate (RIPA buffer, 30µg total protein per lane) stained with ARG63243 anti-SETMAR antibody at 2 µg/ml dilution.
