ARG10653
anti-SERCA2 ATPase antibody
anti-SERCA2 ATPase antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SERCA2 ATPase |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SERCA2 ATPase |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the center region of Human SERCA2 ATPase. 100% homologous in Human, Mouse and Rat. (QRDACLNARCFARVE) |
| 偶联标记 | Un-conjugated |
| 別名 | ATP2B; Endoplasmic reticulum class 1/2 Ca; SERCA2; SR Ca; DD; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; EC 3.6.3.8; Calcium pump 2; DAR; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; 2+ |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.025% Sodium azide and 2.5% BSA. |
| 抗菌剂 | 0.025% Sodium azide |
| 稳定剂 | 2.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ATP2A2 |
| 全名 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
| 背景介绍 | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008] |
| 生物功能 | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. [UniProt] |
| 预测分子量 | 115 kDa |
| 翻译后修饰 | Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity. |
检测图片 (2) Click the Picture to Zoom In
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ARG10653 anti-SERCA2 ATPase antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast cancer tissue stained with ARG10653 anti-SERCA2 ATPase antibody.
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ARG10653 anti-SERCA2 ATPase antibody WB image
Western blot: 1) Rat skeletal muscle, 2) Rat kidney, 3) Human PANC, and 4) SMMC-7721 cell lysates stained with ARG10653 anti-SERCA2 ATPase antibody.
