ARG64746
anti-SEPT7 antibody
anti-SEPT7 antibody for Western blot and Human
Cell Biology and Cellular Response antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes SEPT7 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog, Hrs, Pig |
| 应用 | WB |
| 特异性 | This antibody is expected to recognize all three reported isoforms (NP_001779.3; NP_001011553.2; NP_001229885.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SEPT7 |
| 抗原物种 | Human |
| 抗原 | C-DNNKNKGQLTKSP |
| 偶联标记 | Un-conjugated |
| 別名 | SEPTIN7; Septin 7; Septin-7; SEPT7A; CDC10; SEPT7; CDC3; CDC10 Protein Homolog; CDC10 (Cell Division Cycle 10, S. Cerevisiae, Homolog); CDC10 Cell Division Cycle 10 Homolog (S. Cerevisiae); NBLA02942 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SEPTIN7 |
| 全名 | septin 7 |
| 背景介绍 | This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011] |
| 生物功能 | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). [Uniprot] |
| 细胞定位 | Cell projection, Centromere, Chromosome, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Kinetochore. [Uniprot] |
| 研究领域 | Cell Biology and Cellular Response antibody |
| 预测分子量 | 51 kDa |
| 翻译后修饰 | Acetylation, Phosphoprotein. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
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ARG64746 anti-SEPT7 antibody WB image
Western blot: 35 µg of nuclear HeLa lysate (in RIPA buffer) stained with ARG64746 anti-SEPT7 antibody at 0.5 µg/ml dilution and incubated at RT for 1 hour.
