ARG45158
anti-SCN4B antibody
anti-SCN4B antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SCN4B |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SCN4B |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to middle region of human SCN4B. |
| 偶联标记 | Un-conjugated |
| 別名 | SCN4B; sodium voltage-gated channel beta subunit 4; LQT10; Sodium Channel, Voltage-Gated, Type IV, Beta Subunit; Sodium Channel Subunit Beta-4; Navbeta4; ATFB17 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 28 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SCN4B |
| 全名 | sodium voltage-gated channel beta subunit 4 |
| 背景介绍 | The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009] |
| 生物功能 | Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na+ ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. [UniProt] |
| 细胞定位 | Cell membrane . [UniProt] |
| 预测分子量 | 25 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein. [UniProt] |
检测图片 (7) Click the Picture to Zoom In
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ARG45158 anti-SCN4B antibody IHC-P image
Immunohistochemistry: Human renal cancer stained with ARG45158 anti-SCN4B antibody at 1 μg/ml dilution.
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ARG45158 anti-SCN4B antibody WB image
Western blot: Human placenta, U-87MG, U2OS, HEK293, SHG-44, K562, and HL-60 stained with ARG45158 anti-SCN4B antibody at 0.5 μg/ml dilution.
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ARG45158 anti-SCN4B antibody FACS image
Flow Cytometry: U20S stained with ARG45158 anti-SCN4B antibody at 1 µg/10^6 cells dilution.
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ARG45158 anti-SCN4B antibody IHC-P image
Immunohistochemistry: Rat spleen stained with ARG45158 anti-SCN4B antibody at 1 μg/ml dilution.
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ARG45158 anti-SCN4B antibody WB image
Western blot: Rat brain, rat heart, rat spleen, and rat kidney stained with ARG45158 anti-SCN4B antibody at 0.5 μg/ml dilution.
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ARG45158 anti-SCN4B antibody WB image
Western blot: Mouse brain, mouse heart, mouse spleen, mouse kidney, and mouse Neuro-2a stained with ARG45158 anti-SCN4B antibody at 0.5 μg/ml dilution.
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ARG45158 anti-SCN4B antibody WB image
Western blot: COS-7 stained with ARG45158 anti-SCN4B antibody at 0.5 μg/ml dilution.
