ARG57995
anti-SCARB1 / SRB1 antibody
anti-SCARB1 / SRB1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes SCARB1 / SRB1 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SCARB1 / SRB1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from Human SCARB1 / SR-BI. |
| 偶联标记 | Un-conjugated |
| 別名 | CLA-1; HDLQTL6; CD36L1; CD antigen CD36; CD36 antigen-like 1; CD36 and LIMPII analogous 1; Collagen type I receptor, thrombospondin receptor-like 1; Scavenger receptor class B member 1; SRB1; SR-BI; CLA1 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human fetal liver | ||||||
| 实际分子量 | ~ 76 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q61009 Mouse Scavenger receptor class B member 1 Swiss-port # Q8WTV0 Human Scavenger receptor class B member 1 |
|---|---|
| 基因名称 | SCARB1 |
| 全名 | scavenger receptor class B, member 1 |
| 背景介绍 | The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011] |
| 生物功能 | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester (By similarity). [UniProt] |
| 预测分子量 | 61 kDa |
| 翻译后修饰 | N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
-
ARG57995 anti-SCARB1 / SRB1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver stained with ARG57995 anti-SCARB1 / SRB1 antibody.
-
ARG57995 anti-SCARB1 / SRB1 antibody WB image
Western blot: Human fetal liver lysate stained with ARG57995 anti-SCARB1 / SRB1 antibody.
