ARG45262
anti-SAV1 antibody
anti-SAV1 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Polyclonal antibody recognizes SAV1 |
|---|---|
| 反应物种 | Hu |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | SAV1 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human SAV1. |
| 偶联标记 | Un-conjugated |
| 別名 | SAV1; Salvador Family WW Domain Containing Protein 1; WW45; WWP4; WW Domain-Containing Adaptor 45; Protein Salvador Homolog 1; 45 KDa WW Domain Protein; Salvador; HWW45; Salvador Homolog 1 (Drosophila); Salvador Homolog 1; 1700040G09Rik; SAV |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 45 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | SAV1 |
| 全名 | Salvador Family WW Domain Containing Protein 1 |
| 背景介绍 | WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012] |
| 生物功能 | Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. [UniProt] |
| 细胞定位 | Cytoplasm; Nucleus. [UniProt] |
| 预测分子量 | 45 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
检测图片 (3) Click the Picture to Zoom In
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ARG45262 anti-SAV1 antibody IHC-P image
Immunohistochemistry: Human spleen stained with ARG45262 anti-SAV1 antibody at 2 μg/ml dilution.
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ARG45262 anti-SAV1 antibody WB image
Western blot: DLD-1 and 293T stained with ARG45262 anti-SAV1 antibody at 0.5 μg/ml dilution.
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ARG45262 anti-SAV1 antibody FACS image
Flow Cytometry: U87 stained with ARG45262 anti-SAV1 antibody at 1 µg/10^6 cells dilution.
