ARG44926

anti-SAP18 antibody

anti-SAP18 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human

概述

产品描述 Mouse Monoclonal antibody recognizes SAP18
反应物种 Hu
应用 IHC-P
宿主 Mouse
克隆 Monoclonal
同位型 IgG2a
靶点名称 SAP18
抗原物种 Human
抗原表位 EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP
偶联标记 Un-conjugated
別名 SAP18; Sin3A Associated Protein 18; 2HOR0202; SAP18p; Histone Deacetylase Complex Subunit SAP18; Cell Growth-Inhibiting Gene 38 Protein; 18 KDa Sin3-Associated Polypeptide; Sin3A-Associated Protein, 18kDa; MGC27131; Epididymis Secretory Sperm Binding Protein; Histone Deacetlyase Complex Subunit SAP18; Sin3-Associated Polypeptide, 18 KDa; Cell Growth Inhibiting Protein 38; Sin3-Associated Polypeptide, P18; Sin3-Associated Polypeptide P18

应用说明

应用建议
应用 推荐稀释比
IHC-P1:100~1:200
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式 Liquid
纯化 Protein A purification
缓冲液 PBS with 0.09% sodium azide
抗菌剂 0.09% sodium azide
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 10284 Human SAP18

Swiss-port # O00422 Human Histone deacetylase complex subunit SAP18

基因名称 SAP18
全名 Sin3A Associated Protein 18
背景介绍 Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
生物功能 Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. [UniProt]
细胞定位 Cytoplasm, Nucleus. [UniProt]
预测分子量 18 kDa
翻译后修饰 Acetylation, Isopeptide bond, Ubl conjugation. [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG44926 anti-SAP18 antibody IHC-P image

    Immunohistochemistry: Human testis stained with ARG44926 anti-SAP18 antibody at 7.5 µg/mL dilution.