概述

产品描述	Rabbit Polyclonal antibody recognizes SAMHD1
反应物种	Hu
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	SAMHD1
抗原物种	Human
抗原	Synthetic peptide derived from Human SAMHD1.
偶联标记	Un-conjugated
別名	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; EC 3.1.5.-; SBBI88; SAM domain and HD domain-containing protein 1; HDDC1; MOP-5; DCIP; CHBL2; dNTPase; Dendritic cell-derived IFNG-induced protein; Monocyte protein 5

应用说明

应用建议	应用 推荐稀释比 WB 1:1000 - 1:5000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量	72kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 25939 Human SAMHD1 Swiss-port # Q9Y3Z3 Human Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
基因名称	SAMHD1
全名	SAM domain and HD domain 1
背景介绍	This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. [provided by RefSeq, Mar 2010]
生物功能	Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling. [UniProt]
细胞定位	Nucleus. [UniProt]
预测分子量	72 kDa
翻译后修饰	Ubiquitinated and targeted for proteasomal degradation by a DCX (DDB1-CUL4-X-box) E3 ubiquitin ligase with the help of the viral accessory protein Vpx. [UniProt]

检测图片 (1) Click the Picture to Zoom In