ARG45347
anti-S1P1 / EDG1 antibody [21L9]
anti-S1P1 / EDG1 antibody [21L9] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody [21L9] recognizes S1P1 / EDG1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 21L9 |
| 同位型 | IgG1 |
| 靶点名称 | S1P1 / EDG1 |
| 抗原物种 | Human |
| 抗原 | Recombinant Human S1P1 / EDG1 . |
| 偶联标记 | Un-conjugated |
| 別名 | D1S3362; CD antigen CD363; EDG1; CD363; EDG-1; S1P1; Endothelial differentiation G-protein coupled receptor 1; S1P receptor Edg-1; Sphingosine 1-phosphate receptor Edg-1; Sphingosine 1-phosphate receptor 1; CHEDG1; ECGF1; S1P receptor 1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G chromatography |
| 缓冲液 | PBS |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P21453 Human Sphingosine 1-phosphate receptor 1 |
|---|---|
| 基因名称 | S1PR1 |
| 全名 | sphingosine-1-phosphate receptor 1 |
| 背景介绍 | The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008] |
| 生物功能 | G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. [UniProt] |
| 细胞定位 | Cell membrane; Endosome; Membrane. [UniProt] |
| 预测分子量 | 43 kDa |
| 翻译后修饰 | S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45347 anti-S1P1 / EDG1 antibody [21L9] IHC-P image
Immunohistochemistry: Human placental stained with ARG45347 anti-S1P1 / EDG1 antibody [21L9] at 1:50 dilution.
