ARG44735
anti-S100P antibody
anti-S100P antibody for IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes S100P |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2a |
| 靶点名称 | S100P |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | S100 calcium-binding protein P; MIG9; Protein S100-P; Migration-inducing gene 9 protein; Protein S100-E |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | S100P |
| 全名 | S100 calcium binding protein P |
| 背景介绍 | The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008] |
| 生物功能 | May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). [UniProt] |
| 预测分子量 | 120 kDa |
| 翻译后修饰 | Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335). |
检测图片 (2) Click the Picture to Zoom In
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ARG44735 anti-S100P antibody IHC-P image
Immunohistochemistry: Human placenta stained with ARG44735 anti-S100P antibody at 7.5 µg/mL dilution.
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ARG44735 anti-S100P antibody IP image
Immunoprecipitation: HT29 lysate immunoprecipitated with 2.5 µg of ARG44735 anti-S100P antibody.
