ARG67295
anti-Ryanodine receptor 2 / RYR-2 antibody
anti-Ryanodine receptor 2 / RYR-2 antibody for Western blot and Human,Mouse,Rat,Rabbit
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Ryanodine receptor 2 / RYR-2 |
|---|---|
| 反应物种 | Hu, Ms, Rat, Rb |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 靶点名称 | Ryanodine receptor 2 / RYR-2 |
| 抗原 | KLH-conjugated peptide |
| 偶联标记 | Un-conjugated |
| 別名 | Ryanodine receptor 2; RYR-2; RyR2; hRYR-2; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 564 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | 0.42% Potassium phosphate (pH 7.3), 0.87% NaCl, 0.01% Sodium azide and 30% Glycerol. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 30 % Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | RYR2 |
| 全名 | Ryanodine Receptor 2 |
| 背景介绍 | This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cytosolic calcium-activated calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. [UniProt] |
| 细胞定位 | Sarcoplasmic reticulum membrane. [UniProt] |
| 预测分子量 | 564 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG67295 anti-Ryanodine receptor 2 / RYR-2 antibody WB image
Western blot: PC3 stained with ARG67295 anti-Ryanodine receptor 2 / RYR-2 antibody.
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ARG67295 anti-Ryanodine receptor 2 / RYR-2 antibody WB image
Western blot: Mouse brain stained with ARG67295 anti-Ryanodine receptor 2 / RYR-2 antibody.
