anti-ROS1 antibody [SQab22273]

anti-ROS1 antibody [SQab22273] for IHC-Formalin-fixed paraffin-embedded sections and Human

Cancer antibody; Gene Regulation antibody; Signaling Transduction antibody


产品描述 Recombinant Rabbit Monoclonal antibody [SQab22273] recognizes ROS1
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab22273
同位型 IgG
靶点名称 ROS1
抗原物种 Human
抗原 Recombinant protein fragment of Human ROS1.
偶联标记 Un-conjugated
Protein Full name Proto-oncogene tyrosine-protein kinase ROS
別名 Proto-oncogene c-Ros-1; MCF3; c-ros-1; Receptor tyrosine kinase c-ros oncogene 1; Proto-oncogene tyrosine-protein kinase ROS; c-Ros receptor tyrosine kinase; ROS; EC; Proto-oncogene c-Ros


应用 推荐稀释比
IHC-P1:100 - 1:200
应用说明 IHC-P: Antigen Retrieval: Heat mediated was performed using Tris/EDTA buffer (pH 9.0). Incubate the samples at RT (18-25°C) for 30 min.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Human ROS1+ lung carcinoma tissue


形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05%BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 6098 Human ROS1

Swiss-port # P08922 Human Proto-oncogene tyrosine-protein kinase ROS

基因名称 ROS1
全名 ROS proto-oncogene 1 , receptor tyrosine kinase
背景介绍 This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
生物功能 Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. [UniProt]
细胞定位 Cell membrane; Single-pass type I membrane protein
研究领域 Cancer antibody; Gene Regulation antibody; Signaling Transduction antibody
预测分子量 264 kDa
翻译后修饰 Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation (By similarity). Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity). Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11.

检测图片 (1) Click the Picture to Zoom In

  • ARG66943 anti-ROS1 antibody [SQab22273] IHC-P image

    Immunohistochemistry: Formalin/PFA-fixed and paraffin-embedded sections of Human ROS1+ lung carcinoma tissue stained with ARG66943 anti-ROS1 antibody [SQab22273]. Antigen Retrieval: Heat tissue section in Tris-EDTA buffer (pH 9.0).