ARG46443
anti-RNF121 antibody
anti-RNF121 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes RNF121 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | RNF121 |
| 抗原物种 | Human |
| 抗原 | A 19 amino acid synthetic peptide within the last 50 amino acids of human RNF121. |
| 偶联标记 | Un-conjugated |
| 別名 | RNF121; Ring finger protein 121 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 28 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -493°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | RNF121 |
|---|---|
| 全名 | ring finger protein 121 |
| 背景介绍 | Predicted to enable histone binding activity. Acts upstream of or within mitotic sister chromatid segregation. Predicted to be located in chromosome and nucleus. Predicted to be part of condensin complex. Predicted to be active in condensed chromosome, centromeric region. Is expressed in nervous system; optic cup; pectoral fin; pharyngeal arch 3-7 skeleton; and proliferative region. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 21. Orthologous to human NCAPD2 (non-SMC condensin I complex subunit D2). [provided by Alliance of Genome Resources, Apr 2025] |
| 生物功能 | E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity). May regulate the unfolded protein response to reduce endoplasmic reticulum stress (By similarity). [UniProt] |
| 细胞定位 | Endoplasmic reticulum membrane. [UniProt] |
| 预测分子量 | 24, 27, 36 kDa |
