ARG42415
anti-RLTPR antibody [EM-53] (PE)
anti-RLTPR antibody [EM-53] (PE) for Flow cytometry and Human,Mouse
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [EM-53] recognizes RLTPR |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody EM-53 recognizes RLTPR / CARMIL2, an intracellular protein playing a role in actin filament elongation. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | EM-53 |
| 同位型 | IgG1, kappa |
| 靶点名称 | RLTPR |
| 抗原物种 | Mouse |
| 抗原 | Murine RLTPR. |
| 偶联标记 | PE |
| 別名 | CARMIL2b; CARMIL2; Leucine-rich repeat-containing protein 16C; LRRC16C; RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q3V3V9 Mouse Leucine-rich repeat-containing protein 16C Swiss-port # Q6F5E8 Human Leucine-rich repeat-containing protein 16C |
|---|---|
| 基因名称 | RLTPR |
| 全名 | RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing |
| 背景介绍 | This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017] |
| 生物功能 | Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization (PubMed:26466680). Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved as well in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper and T regulatory cells (PubMed:27647349, PubMed:27647348, PubMed:28112205). [UniProt] |
| 细胞定位 | Isoform 2: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle. Note=Colocalizes to dynamic vimentin filaments both in the central cytoplasm and at leading edges of migrating cells (PubMed:26578515, PubMed:26466680, PubMed:19846667). Colocalizes with F-actin, Arp2/3 complex and cortactin to leading edge lamellipodia, ruffles and macropinosomes of migrating cells (PubMed:26578515). [UniProt] |
| 预测分子量 | 155 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG42415 anti-RLTPR antibody [EM-53] (PE) FACS image
Flow Cytometry: Separation of stained RLTPR transfected cells (red) from unstained RLTPR transfected cells (black). Cells were stained with ARG42415 anti-RLTPR antibody [EM-53] (PE) at 27 µg/ml dilution.
