ARG45191
anti-RGS6 antibody
anti-RGS6 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes RGS6 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | RGS6 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human RGS6. |
| 偶联标记 | Un-conjugated |
| 別名 | RGS6; Regulator Of G Protein Signaling 6; Regulator Of G-Protein Signaling 6; Regulator Of G-Protein Signalling 6; S914;HA117; GAP |
应用说明
| 应用建议 |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 54 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.01% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P49758 Human Regulator of G-protein signaling 6 Swiss-port # Q9Z2H2 Mouse Regulator of G-protein signaling 6 |
|---|---|
| 基因名称 | RGS6 |
| 全名 | Regulator Of G Protein Signaling 6 |
| 背景介绍 | This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011] |
| 生物功能 | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity. [UniProt] |
| 细胞定位 | Cell membrane; Cytoplasm; Membrane; Nucleus [UniProt] |
| 预测分子量 | 54 kDa |
检测图片 (5) Click the Picture to Zoom In
-
ARG45191 anti-RGS6 antibody IHC-P image
Immunohistochemistry: Human bladder cancer stained with ARG45191 anti-RGS6 antibody at 2 μg/ml dilution.
-
ARG45191 anti-RGS6 antibody WB image
Western blot: T47D, MCF-7, and Hela stained with ARG45191 anti-RGS6 antibody at 0.5 μg/ml dilution.
-
ARG45191 anti-RGS6 antibody FACS image
Flow Cytometry: MCF-7 stained with ARG45191 anti-RGS6 antibody at 1 µg/10^6 cells dilution.
-
ARG45191 anti-RGS6 antibody WB image
Western blot: Rat heart stained with ARG45191 anti-RGS6 antibody at 0.5 μg/ml dilution.
-
ARG45191 anti-RGS6 antibody WB image
Western blot: Mouse kidney stained with ARG45191 anti-RGS6 antibody at 0.5 μg/ml dilution.
