概述

产品描述	Rabbit Polyclonal antibody recognizes RGS10
反应物种	Hu
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	RGS10
抗原物种	Human
抗原	Synthetic peptide within aa. 50-130 of Human RGS10.
偶联标记	Un-conjugated
別名	Regulator of G-protein signaling 10; RGS10

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量	20 kDa

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS, 0.02% Sodium azide, 50% Glycerol and 0.5% BSA.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol and 0.5% BSA
浓度	1 mg/ml
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 6001 Human RGS10 Swiss-port # O43665 Human Regulator of G-protein signaling 10
基因名称	RGS10
全名	regulator of G-protein signaling 10
背景介绍	Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
生物功能	Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)-alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. [UniProt]
细胞定位	Cytoplasm, cytosol. Nucleus. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus. Isoform 2: Nucleus. [UniProt]
预测分子量	21 kDa
翻译后修饰	Isoform 3 is phosphorylated on Ser-16. [UniProt]

检测图片 (1) Click the Picture to Zoom In