概述

产品描述	Rabbit Polyclonal antibody recognizes RFXANK
反应物种	Hu
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	RFXANK
抗原物种	Human
抗原	Synthetic peptide
偶联标记	Un-conjugated
別名	RFXANK; Regulatory Factor X Associated Ankyrin Containing Protein; ANKRA1; RFX-B; Regulatory Factor X Subunit B; DNA-Binding Protein RFXANK

应用说明

应用建议	应用 推荐稀释比 WB 1:500-1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

属性

形式	Liquid
纯化	Antigen Affinity Purified
缓冲液	PBS with 0.02% Sodium azide
抗菌剂	0.02% Sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 8625 Human RFXANK Swiss-port # O14593 Human DNA-binding protein RFXANK
基因名称	RFXANK
全名	Regulatory Factor X Associated Ankyrin Containing Protein
背景介绍	Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
生物功能	Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters.
细胞定位	Cytoplasm, Nucleus
预测分子量	28 kDa

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