ARG46429
anti-RFX1 antibody
anti-RFX1 antibody for Western blot,ICC/IF and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes RFX1 |
|---|---|
| 反应物种 | Hu |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | RFX1 |
| 抗原物种 | Human |
| 抗原 | A 18 amino acid synthetic peptide within the last 50 amino acids of human RFX1. |
| 偶联标记 | Un-conjugated |
| 別名 | regulatory factor X, 1 (influences HLA class II expression); RFX; MHC class II regulatory factor RFX; MHC class II regulatory factor RFX1; enhancer factor C; EFC; trans-acting regulatory factor 1; transcription factor RFX1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 125 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -479°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P22670 Human MHC class II regulatory factor RFX1 |
|---|---|
| 基因名称 | RFX1 |
| 全名 | regulatory factor X, 1 (influences HLA class II expression) |
| 背景介绍 | This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016] |
| 生物功能 | Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 108 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt] |
