ARG58743
anti-RECK antibody
anti-RECK antibody for Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes RECK |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | RECK |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 110-210 of Human RECK (NP_066934.1). |
| 偶联标记 | Un-conjugated |
| 別名 | Reversion-inducing cysteine-rich protein with Kazal motifs; hRECK; ST15; Suppressor of tumorigenicity 15 protein |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | 293T | ||||
| 实际分子量 | 110 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O95980 Human Reversion-inducing cysteine-rich protein with Kazal motifs Swiss-port # Q9Z0J1 Mouse Reversion-inducing cysteine-rich protein with Kazal motifs |
|---|---|
| 基因名称 | RECK |
| 全名 | reversion-inducing-cysteine-rich protein with kazal motifs |
| 背景介绍 | The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. [UniProt] |
| 细胞定位 | Cell membrane, Lipid-anchor, GPI-anchor. [UniProt] |
| 预测分子量 | 106 kDa |
| 翻译后修饰 | N-glycosylated. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58743 anti-RECK antibody WB image
Western blot: 25 µg of 293T cell lysate stained with ARG58743 anti-RECK antibody at 1:1000 dilution.
