ARG41302
anti-RBBP6 antibody
anti-RBBP6 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes RBBP6 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | RBBP6 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein corresponding to aa. 97-351 of Human RBBP6. |
| 偶联标记 | Un-conjugated |
| 別名 | PACT; Retinoblastoma-binding protein 6; E3 ubiquitin-protein ligase RBBP6; EC 6.3.2.-; SNAMA; Proliferation potential-related protein; RBQ-1; Protein P2P-R; Retinoblastoma-binding Q protein 1; MY038; P2P-R; p53-associated cellular protein of testis |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | Mouse brain |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | 0.01M PBS (pH 7.4), 0.03% Proclin 300 and 50% Glycerol. |
| 抗菌剂 | 0.03% Proclin 300 |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | RBBP6 |
| 全名 | retinoblastoma binding protein 6 |
| 背景介绍 | The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth. [UniProt] |
| 细胞定位 | Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome. [UniProt] |
| 预测分子量 | 202 kDa |
| 翻译后修饰 | Phosphorylated by NEK6. [UniProt] |
检测图片 (4) Click the Picture to Zoom In
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ARG41302 anti-RBBP6 antibody ICC/IF image
Immunofluorescence: HeLa cells stained with ARG41302 anti-RBBP6 antibody at 1:100 dilution.
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ARG41302 anti-RBBP6 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human cervical cancer tissue stained with ARG41302 anti-RBBP6 antibody at 1:100 dilution.
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ARG41302 anti-RBBP6 antibody WB image
Western blot: Mouse brain lysate stained with ARG41302 anti-RBBP6 antibody at 3 µg/ml dilution.
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ARG41302 anti-RBBP6 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human testis tissue stained with ARG41302 anti-RBBP6 antibody at 1:100 dilution.
