ARG64669
anti-RAB17 antibody
anti-RAB17 antibody for Western blot and Mouse
Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes RAB17 |
|---|---|
| 反应物种 | Ms |
| 预测物种 | Rat |
| 应用 | WB |
| 特异性 | Reported variants represent identical protein (NP_001153197.2; NP_033024.1). |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | RAB17 |
| 抗原物种 | Mouse |
| 抗原 | C-RKDSFHKAQQWLED |
| 偶联标记 | Un-conjugated |
| 別名 | Ras-related protein Rab-17 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Rab17 |
| 全名 | RAB17, member RAS oncogene family |
| 背景介绍 | The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 [PubMed 8486736]).[supplied by OMIM, Oct 2009] |
| 生物功能 | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration. [UniProt] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 23 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG64669 anti-RAB17 antibody WB image
Western blot: Mouse Kidney lysate (35 µg protein in RIPA buffer) stained with ARG64669 anti-RAB17 antibody at 0.2 µg/ml dilution.
