ARG41415

anti-Protein C antibody

anti-Protein C antibody for Western blot and Mouse,Rat

概述

产品描述 Rabbit Polyclonal antibody recognizes Protein C
反应物种 Ms, Rat
应用 WB
宿主 Rabbit
克隆 Polyclonal
同位型 IgG
靶点名称 Protein C
抗原物种 Human
抗原 Recombinant protein corresponding to D200-P461 of Human Protein C.
偶联标记 Un-conjugated
別名 EC 3.4.21.69; Blood coagulation factor XIV; PC; THPH3; Vitamin K-dependent protein C; THPH4; APC; Autoprothrombin IIA; PROC1; Anticoagulant protein C

应用说明

应用建议
应用 推荐稀释比
WB1:500 - 1:2000
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
实际分子量 ~ 53 kDa

属性

形式 Liquid
纯化 Affinity purification with immunogen.
缓冲液 0.2% Na2HPO4, 0.9% NaCl, 0.05% Sodium azide and 4% Trehalose.
抗菌剂 0.05% Sodium azide
稳定剂 4% Trehalose
浓度 0.5 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接

GeneID: 19123 Mouse PROC

GeneID: 25268 Rat PROC

Swiss-port # P31394 Rat Vitamin K-dependent protein C

Swiss-port # P33587 Mouse Vitamin K-dependent protein C

基因名称 PROC
全名 protein C (inactivator of coagulation factors Va and VIIIa)
背景介绍 This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]
生物功能 Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. [UniProt]
细胞定位 Secreted. Golgi apparatus. Endoplasmic reticulum. [UniProt]
预测分子量 52 kDa
翻译后修饰 The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.

N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide. [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG41415 anti-Protein C antibody WB image

    Western blot: 50 µg of samples under reducing conditions. Rat liver and Mouse liver lysates stained with ARG41415 anti-Protein C antibody at 0.5 µg/ml dilution, overnight at 4°C.