ARG11164
anti-Proinsulin antibody [CCI-17]
anti-Proinsulin antibody [CCI-17] for ELISA and Rat
Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody
概述
| 产品描述 | Mouse Monoclonal antibody [CCI-17] recognizes Proinsulin |
|---|---|
| 反应物种 | Rat |
| 应用 | ELISA |
| 特异性 | This antibody binds specifically to proinsulin and does not bind to insulin or C-peptide. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | CCI-17 |
| 同位型 | IgG1 |
| 靶点名称 | Proinsulin |
| 抗原物种 | Rat |
| 抗原 | Immunized with fragment of rat proinsulin conjugated with a carrier protein. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Proinsulin |
| 別名 | IDDM; IDDM2; IDDM1; ILPR; MODY10; Insulin; IRDN |
应用说明
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A affinity purified. |
| 缓冲液 | PBS (pH 7.4) and 0.1% Sodium azide |
| 抗菌剂 | 0.1% Sodium azide |
| 浓度 | 2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | INS |
|---|---|
| 全名 | insulin |
| 背景介绍 | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] |
| 生物功能 | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. [UniProt] |
| 细胞定位 | Secreted |
| 研究领域 | Cell Biology and Cellular Response antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
| 预测分子量 | 12 kDa |
| 翻译后修饰 | Cleavage on pair of basic residues; Disulfide bond |
