ARG45375
anti-Progranulin antibody [34U21]
anti-Progranulin antibody [34U21] for Western blot and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [34U21] recognizes Progranulin |
|---|---|
| 反应物种 | Ms |
| 应用 | WB |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 34U21 |
| 同位型 | IgG2 |
| 靶点名称 | Progranulin |
| 抗原物种 | Mouse |
| 抗原 | Recombinant Mouse Progranulin. |
| 偶联标记 | Un-conjugated |
| 別名 | PEPI; Glycoprotein 88; CLN11; GEP; Proepithelin; Granulin E; Granulin D; Granulins; PGRN; Glycoprotein of 88 Kda; Granulin G; Progranulin; PCDGF; Granulin B; Granulin C; Granulin A; GP88; Granulin F |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G chromatography |
| 缓冲液 | PBS |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | GRN |
|---|---|
| 全名 | granulin |
| 背景介绍 | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008] |
| 生物功能 | Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. [UniProt] |
| 产品亮点 | Related products: Progranulin antibodies; Progranulin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 预测分子量 | 64 kDa |
| 翻译后修饰 | Granulins are disulfide bridged. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45375 anti-Progranulin antibody [34U21] WB image
Western blot: Mouse ulterus stained with ARG45375 anti-Progranulin antibody [34U21].
