anti-Perforin antibody [deltaG9]

anti-Perforin antibody [deltaG9] for Flow cytometry,ICC/IF,Immunohistochemistry,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation and Human

Immune System antibody


产品描述 Mouse Monoclonal antibody [deltaG9] recognizes Perforin
反应物种 Hu
宿主 Mouse
克隆 Monoclonal
克隆号 deltaG9
同位型 IgG2b
靶点名称 Perforin
抗原物种 Human
抗原 Purified granules from human YT lymphoma cells
偶联标记 Un-conjugated
別名 FLH2; P1; PFN1; Cytolysin; HPLH2; PFP; Lymphocyte pore-forming protein; Perforin-1


应用 推荐稀释比
FACS2 - 8 µg/ml
ICC/IF2 - 8 µg/ml
IHC-P2 - 8 µg/ml
IP2 - 8 µg/ml
应用说明 * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.


形式 Liquid
纯化 Affinity purified
缓冲液 1X PBS buffer with <0.1% sodium azide.
抗菌剂 <0.1% sodium azide.
浓度 2 mg/ml
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 5551 Human PRF1

Swiss-port # P14222 Human Perforin-1

基因名称 PRF1
全名 perforin 1 (pore forming protein)
背景介绍 Perforin with structural similarities to complement component C9 that is important in immunity. This protein forms membrane pores that allow the release of granzymes and subsequent cytolysis of target cells. Whether pore formation occurs in the plasma membrane of target cells or in an endosomal membrane inside target cells is subject to debate. Mutations in this gene are associated with a variety of human disease including diabetes, multiple sclerosis, lymphomas, autoimmune lymphoproliferative syndrome (ALPS), aplastic anemia, and familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood. [provided by RefSeq, Aug 2017]
生物功能 Perforin plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. [UniProt]
产品亮点 Related products:
Perforin antibodies; Perforin ELISA Kits; Anti-Mouse IgG secondary antibodies;
Related news:
Examining CTL/NK-mediated cytotoxicity by ELISA
研究领域 Immune System antibody
预测分子量 61 kDa
翻译后修饰 N-glycosylated.