ARG45123
anti-Patched 1 antibody
anti-Patched 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Chicken,Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Patched 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat, Chk |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Patched 1 |
| 抗原物种 | Mouse |
| 偶联标记 | Un-conjugated |
| 別名 | PTCH1; Patched 1; BCNS; PTCH; Protein Patched Homolog 1; NBCCS; PTC1; PTC; Patched Homolog 1 (Drosophila); Patched (Drosophila) Homolog; Patched Homolog (Drosophila); BCNS1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antigen Affinity Purified |
| 缓冲液 | PBS with 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PTCH1 |
| 全名 | Patched 1 |
| 背景介绍 | This gene encodes a member of the patched family of proteins and a component of the hedgehog signaling pathway. Hedgehog signaling is important in embryonic development and tumorigenesis. The encoded protein is the receptor for the secreted hedgehog ligands, which include sonic hedgehog, indian hedgehog and desert hedgehog. Following binding by one of the hedgehog ligands, the encoded protein is trafficked away from the primary cilium, relieving inhibition of the G-protein-coupled receptor smoothened, which results in activation of downstream signaling. Mutations of this gene have been associated with basal cell nevus syndrome and holoprosencephaly. [provided by RefSeq, Aug 2017] |
| 生物功能 | Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. [Uniprot] |
| 细胞定位 | Cell membrane; Membrane. [Uniprot] |
| 预测分子量 | 161 kDa |
| 翻译后修饰 | Glycoprotein; Isopeptide bond; Phosphoprotein; Ubl conjugation. [Uniprot] |
