ARG59981
anti-PUS1 antibody
anti-PUS1 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PUS1 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PUS1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 308-427 of Human PUS1 (NP_079491.2). |
| 偶联标记 | Un-conjugated |
| 別名 | tRNA pseudouridine synthase A, mitochondrial; tRNA-uridine isomerase I; 38-40; tRNA pseudouridine; EC 5.4.99.12; tRNA pseudouridylate synthase I; MLASA1 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | U87 | ||||
| 实际分子量 | 47 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y606 Human tRNA pseudouridine synthase A, mitochondrial |
|---|---|
| 基因名称 | PUS1 |
| 全名 | pseudouridylate synthase 1 |
| 背景介绍 | This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009] |
| 生物功能 | Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity). [UniProt] |
| 细胞定位 | Isoform 1: Mitochondrion. Isoform 2: Nucleus. [UniProt] |
| 预测分子量 | 47 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG59981 anti-PUS1 antibody WB image
Western blot: 25 µg of U87 cell lysate stained with ARG59981 anti-PUS1 antibody at 1:1000 dilution.
