ARG42819
anti-PTPRR / PTPRQ antibody
anti-PTPRR / PTPRQ antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PTPRR / PTPRQ |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PTPRR / PTPRQ |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human PTPRR / PTPRQ. |
| 偶联标记 | Un-conjugated |
| 別名 | PCPTP1; PTPBR7; PTP-SL; R-PTP-R; PTPRQ; EC-PTP; Protein-tyrosine phosphatase PCPTP1; Ch-1PTPase; Receptor-type tyrosine-protein phosphatase R; EC 3.1.3.48; NC-PTPCOM1 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Rat brain | ||||
| 实际分子量 | ~ 74 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 浓度 | Batch dependent |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PTPRR |
| 全名 | protein tyrosine phosphatase, receptor type, R |
| 背景介绍 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011] |
| 生物功能 | Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity). [UniProt] |
| 细胞定位 | Isoform Alpha: Cell membrane; Single-pass type I membrane protein. Isoform Delta: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm. Isoform Gamma: Cytoplasm, perinuclear region. Note=Locates to the perinuclear areas within the cytoplasm. [UniProt] |
| 预测分子量 | 74 kDa |
检测图片 (1) Click the Picture to Zoom In
-
ARG42819 anti-PTPRR / PTPRQ antibody WB image
Western blot: Rat brain lysate stained with ARG42819 anti-PTPRR / PTPRQ antibody at 1:1000 dilution.
