ARG44902
anti-PTPRN antibody
anti-PTPRN antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes PTPRN |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | PTPRN |
| 抗原物种 | Human |
| 抗原表位 | VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE LEAQTGLQIL QTGVGQREEA AAVLPQTAHS |
| 偶联标记 | Un-conjugated |
| 別名 | PTPRN; Protein Tyrosine Phosphatase Receptor Type N; ICA512; Islet Cell Antigen 512; IA-2; Insulinoma-Associated Tyrosine-Phosphatase-Like Protein; Receptor-Type Tyrosine-Protein Phosphatase-Like N; Islet Cell Autoantigen 3; PTP IA-2; R-PTP-N; ICA 512; Protein Tyrosine Phosphatase-Like N; Islet Cell Antigen 2; EC 3.1.3.48; IA-2/PTP; ICA3; IA2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purified. |
| 缓冲液 | PBS with 0.09% sodium azide |
| 抗菌剂 | 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q16849 Human Receptor-type tyrosine-protein phosphatase-like N |
|---|---|
| 基因名称 | PTPRN |
| 全名 | Protein Tyrosine Phosphatase Receptor Type N |
| 背景介绍 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] |
| 生物功能 | Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization. [Uniprot] |
| 细胞定位 | Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane, Nucleus, Synapse. [Uniprot] |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
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ARG44902 anti-PTPRN antibody IHC-P image
Immunohistochemistry: Human pancreas stained with ARG44902 anti-PTPRN antibody at 5 µg/mL dilution.
