ARG43995
anti-PSMC5 / TRIP1 antibody
anti-PSMC5 / TRIP1 antibody for ELISA,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PSMC5 / TRIP1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ELISA, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PSMC5 / TRIP1 |
| 抗原物种 | Human |
| 抗原 | Human PSMC5 / TRIP1 recombinant protein |
| 表达系统 | E.coli |
| 偶联标记 | Un-conjugated |
| Protein Full name | 26S proteasome regulatory subunit 8 |
| 別名 | PSMC5; Proteasome 26S Subunit, ATPase 5; P45/SUG; TRIP1; SUG1; TBP10; SUG-1; RPT6; P45; S8; Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5; Thyroid Hormone Receptor-Interacting Protein 1; 26S Proteasome AAA-ATPase Subunit RPT6; 26S Proteasome Regulatory Subunit 8; Proteasome Subunit P45; 26S Protease Regulatory Subunit 8; Testicular Tissue Protein Li 149; Proteasome 26S ATPase Subunit 5; Proteasome 26S Subunit ATPase 5; Tat-Binding Protein Homolog 10; Thyroid Receptor Interactor 1; MSUG1 Protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PSMC5 |
| 全名 | Proteasome 26S Subunit, ATPase 5 |
| 背景介绍 | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. |
| 生物功能 | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. |
| 细胞定位 | Cytoplasm, Nucleus, Proteasome |
| 预测分子量 | 46 kDa |
| 翻译后修饰 | Acetylation, Phosphoprotein |
检测图片 (3) Click the Picture to Zoom In
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ARG43995 anti-PSMC5 / TRIP1 antibody WB image
Western blot: SK-OV-3 and MCF-7 stained with ARG43995 anti-PSMC5 / TRIP1 antibody at 0.5 μg/mL dilution.
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ARG43995 anti-PSMC5 / TRIP1 antibody WB image
Western blot: PC-12 stained with ARG43995 anti-PSMC5 / TRIP1 antibody at 0.5 μg/mL dilution.
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ARG43995 anti-PSMC5 / TRIP1 antibody WB image
Western blot: Mouse kidney and NIH/3T3 stained with ARG43995 anti-PSMC5 / TRIP1 antibody at 0.5 μg/mL dilution.
