ARG64568
anti-PRUNE2 / BMCC1 antibody
anti-PRUNE2 / BMCC1 antibody for Western blot and Human
Cell Biology and Cellular Response antibody; Cell Death antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes PRUNE2 / BMCC1 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Dog |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PRUNE2 / BMCC1 |
| 抗原物种 | Human |
| 抗原 | C-MESEKISEKQEE |
| 偶联标记 | Un-conjugated |
| 別名 | KIAA0367; Protein prune homolog 2; C9orf65; BNIPXL; BMCC1; BNIP2 motif-containing molecule at the C-terminal region 1 |
应用说明
| 应用建议 |
|
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PRUNE2 |
| 全名 | prune homolog 2 (Drosophila) |
| 背景介绍 | The protein encoded by this gene belongs to the B-cell CLL/lymphoma 2 and adenovirus E1B 19 kDa interacting family, whose members play roles in many cellular processes including apotosis, cell transformation, and synaptic function. Several functions for this protein have been demonstrated including suppression of Ras homolog family member A activity, which results in reduced stress fiber formation and suppression of oncogenic cellular transformation. A high molecular weight isoform of this protein has also been shown to colocalize with Adaptor protein complex 2, beta-Adaptin and endodermal markers, suggesting an involvement in post-endocytic trafficking. In prostate cancer cells, this gene acts as a tumor suppressor and its expression is regulated by prostate cancer antigen 3, a non-protein coding gene on the opposite DNA strand in an intron of this gene. Prostate cancer antigen 3 regulates levels of this gene through formation of a double-stranded RNA that undergoes adenosine deaminase actin on RNA-dependent adenosine-to-inosine RNA editing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015] |
| 生物功能 | May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Cell Death antibody |
| 预测分子量 | 341 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG64568 anti-PRUNE2 / BMCC1 antibody WB image
Western Blot: Human Brain lysate (35 µg protein in RIPA buffer) stained with ARG64568 anti-PRUNE2 / BMCC1 antibody at 1 µg/ml dilution.
