ARG65605
anti-PRMT7 antibody
anti-PRMT7 antibody for Western blot and Human,Mouse
Gene Regulation antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes PRMT7 |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Dog, Rat |
| 应用 | WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 靶点名称 | PRMT7 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the center region of Human PRMT7 (C-PRFGEINDQDRTDR) |
| 偶联标记 | Un-conjugated |
| 別名 | EC 2.1.1.126; EC 2.1.1.125; Protein arginine N-methyltransferase 7; Histone-arginine N-methyltransferase PRMT7; EC 2.1.1.-; [Myelin basic protein]-arginine N-methyltransferase PRMT7 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q922X9 Mouse Protein arginine N-methyltransferase 7 Swiss-port # Q9NVM4 Human Protein arginine N-methyltransferase 7 |
|---|---|
| 基因名称 | PRMT7 |
| 全名 | protein arginine methyltransferase 7 |
| 背景介绍 | Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM, Mar 2008] |
| 生物功能 | Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. |
| 研究领域 | Gene Regulation antibody |
| 预测分子量 | 78 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG65605 anti-PRMT7 antibody WB image
Western blot: 35 μg of HeLa lysate stained with ARG65605 anti-PRMT7 antibody at 0.3 μg/ml dilution (1h incubation).
