ARG43953
anti-PREX2 antibody
anti-PREX2 antibody for ELISA,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PREX2 |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PREX2 |
| 抗原物种 | Human |
| 抗原 | Human PREX2 recombinant protein |
| 表达系统 | E.coli |
| 偶联标记 | Un-conjugated |
| Protein Full name | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein |
| 別名 | PREX2; Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2; PPP1R129; P-REX2; DEPDC2; DEP.2; Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Rac Exchanger 2 Protein; Protein Phosphatase 1, Regulatory Subunit 129; PtdIns(3,4,5)-Dependent Rac Exchanger 2; DEP Domain-Containing Protein 2; FLJ12987; Phosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 2; DEP Domain Containing 2; P-Rex2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 |
Swiss-port # Q70Z35 Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein |
|---|---|
| 基因名称 | PREX2 |
| 全名 | Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2 |
| 背景介绍 | The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. |
| 生物功能 | Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. |
| 细胞定位 | Cytosol, Plasma membrane |
| 预测分子量 | 183 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG43953 anti-PREX2 antibody WB image
Western blot: Mouse skeletal muscle stained with ARG43953 anti-PREX2 antibody at 0.5 μg/mL dilution.
