ARG43952
anti-PRDM8 antibody
anti-PRDM8 antibody for ELISA,Flow cytometry,ICC/IF,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PRDM8 |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, FACS, ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PRDM8 |
| 抗原物种 | Human |
| 抗原 | Human PRDM8 recombinant protein |
| 表达系统 | E.coli |
| 偶联标记 | Un-conjugated |
| Protein Full name | PR domain zinc finger protein 8 |
| 別名 | PRDM8; PR/SET Domain 8; KMT8D; PR Domain Zinc Finger Protein 8; PR Domain 8; PFM5; PR-Domain Containing Protein 8; PR Domain-Containing Protein 8; PR Domain Containing 8; EC 2.1.1.-; EPM10 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PRDM8 |
| 全名 | PR/SET Domain 8 |
| 背景介绍 | This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has been shown to interact with the phosphatase laforin and the ubiquitin ligase malin, which regulate glycogen construction in the cytoplasm. Alternative splicing results in multiple transcript variants. |
| 生物功能 | Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR. |
| 细胞定位 | Nucleus |
| 预测分子量 | 72 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG43952 anti-PRDM8 antibody ICC/IF image
Immunofluorescence: A431 cells stained with ARG43952 anti-PRDM8 antibody at 5 μg/ml dilution.
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ARG43952 anti-PRDM8 antibody WB image
Western blot: MCF-7 stained with ARG43952 anti-PRDM8 antibody at 0.5 μg/mL dilution.
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ARG43952 anti-PRDM8 antibody FACS image
Flow Cytometry: A431 cells stained withARG43952 anti-PRDM8 antibody (blue) at 1 μg/1x10^6 cells dilution.
