anti-PRDM1 / Blimp 1 antibody
anti-PRDM1 / Blimp 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Gene Regulation antibody; Immune System antibody
|产品描述||Rabbit Polyclonal antibody recognizes PRDM1 / Blimp 1|
|靶点名称||PRDM1 / Blimp 1|
|抗原||Synthetic peptide (17 aa) within aa. 100-150 of Human PRDM1 / Blimp1.|
|別名||Beta-interferon gene positive regulatory domain I-binding factor; PR domain zinc finger protein 1; BLIMP-1; BLIMP1; PRDI-binding factor 1; PR domain-containing protein 1; EC 2.1.1.-; PRDI-BF1; Positive regulatory domain I-binding factor 1|
|应用说明||* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.|
|阳性对照||Mouse Lung Tissue Lysate|
|纯化||Affinity purification with immunogen.|
|缓冲液||PBS and 0.02% Sodium azide|
|抗菌剂||0.02% Sodium azide|
|存放说明||For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.|
|注意事项||For laboratory research only, not for drug, diagnostic or other use.|
Swiss-port # O75626 Human PR domain zinc finger protein 1
|全名||PR domain containing 1, with ZNF domain|
|背景介绍||This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]|
|生物功能||Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. [UniProt]|
|研究领域||Gene Regulation antibody; Immune System antibody|
|翻译后修饰||Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.
Ubiquitinated by the SCF(FBXO11) complex, leading to its degradation by the proteasome.
检测图片 (2) Click the Picture to Zoom In
ARG55270 anti-PRDM1 / Blimp 1 antibody IHC-P image
Immunohistochemistry: Mouse lung tissue stained with ARG55270 anti-PRDM1 / Blimp 1 antibody at 5 µg/ml dilution.
ARG55270 anti-PRDM1 / Blimp 1 antibody WB image
Western blot: Mouse lung tissue lysate stained with ARG55270 anti-PRDM1 / Blimp 1 antibody.