anti-PRAME antibody [SQab30314]

anti-PRAME antibody [SQab30314] for IHC-Formalin-fixed paraffin-embedded sections and Human


产品描述 Recombinant rabbit Monoclonal antibody [SQab30314] recognizes PRAME
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab30314
同位型 IgG
靶点名称 PRAME
抗原物种 Human
抗原 Recombinant protein of Human PRAME.
偶联标记 Un-conjugated
Protein Full name Melanoma antigen preferentially expressed in tumors
別名 PRAME, PRAME Nuclear Receptor Transcriptional Regulator, CT130, MAPE, Melanoma Antigen Preferentially Expressed In Tumors, Preferentially Expressed Antigen In Melanoma, Preferentially Expressed Antigen Of Melanoma, Cancer/Testis Antigen 130, Opa-Interacting Protein 4, OIP-4, OIP4, Opa-Interacting Protein OIP4


应用 推荐稀释比
IHC-P1:50 - 1:100
应用说明 The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照 Human malignant melanoma


形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05%BSA
存放说明 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项 For laboratory research only, not for drug, diagnostic or other use.



GeneID: 23532 Human PRAME

Swiss-port # P78395 Human Melanoma antigen preferentially expressed in tumors

基因名称 PRAME
全名 PRAME Nuclear Receptor Transcriptional Regulator
背景介绍 This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
生物功能 Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation.The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. [Uniprot]
细胞定位 Cell membrane, Chromosome, Cytoplasm, Golgi apparatu, Membran, Nucleus
预测分子量 58 kDa
翻译后修饰 Phosphoprotein.[Uniprot]

检测图片 (1) Click the Picture to Zoom In

  • ARG67043 anti-PRAME antibody [SQab30314] IHC-P image

    Immunohistochemistry: Formalin-fixed and paraffin-embedded human malignant melanoma stained with ARG67043 anti-PRAME antibody [SQab30314].