ARG67043
anti-PRAME antibody [SQab30314]
anti-PRAME antibody [SQab30314] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant rabbit Monoclonal antibody [SQab30314] recognizes PRAME |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30314 |
| 同位型 | IgG |
| 靶点名称 | PRAME |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human PRAME. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Melanoma antigen preferentially expressed in tumors |
| 別名 | PRAME, PRAME Nuclear Receptor Transcriptional Regulator, CT130, MAPE, Melanoma Antigen Preferentially Expressed In Tumors, Preferentially Expressed Antigen In Melanoma, Preferentially Expressed Antigen Of Melanoma, Cancer/Testis Antigen 130, Opa-Interacting Protein 4, OIP-4, OIP4, Opa-Interacting Protein OIP4 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Human malignant melanoma |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05%BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P78395 Human Melanoma antigen preferentially expressed in tumors |
|---|---|
| 基因名称 | PRAME |
| 全名 | PRAME Nuclear Receptor Transcriptional Regulator |
| 背景介绍 | This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| 生物功能 | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation.The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. [Uniprot] |
| 细胞定位 | Cell membrane, Chromosome, Cytoplasm, Golgi apparatu, Membran, Nucleus |
| 预测分子量 | 58 kDa |
| 翻译后修饰 | Phosphoprotein.[Uniprot] |
检测图片 (1) Click the Picture to Zoom In
-
ARG67043 anti-PRAME antibody [SQab30314] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded human malignant melanoma stained with ARG67043 anti-PRAME antibody [SQab30314].
