ARG43950
anti-PPP1R15B antibody
anti-PPP1R15B antibody for ELISA,Flow cytometry,ICC/IF,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PPP1R15B |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA, FACS, ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PPP1R15B |
| 抗原物种 | Human |
| 抗原 | Human PPP1R15B recombinant protein |
| 表达系统 | E.coli |
| 偶联标记 | Un-conjugated |
| Protein Full name | Protein phosphatase 1 regulatory subunit 15B |
| 別名 | PPP1R15B; Protein Phosphatase 1 Regulatory Subunit 15B; Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15B; FLJ14744 ; Protein Phosphatase 1, Regulatory Subunit 15B; MSSGM2; CREP |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified with Immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | PPP1R15B |
|---|---|
| 全名 | Protein Phosphatase 1 Regulatory Subunit 15B |
| 背景介绍 | This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. |
| 生物功能 | Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1. |
| 细胞定位 | Diabetes mellitus, Disease variant, Dwarfism, Intellectual disability |
| 预测分子量 | 79 kDa |
| 翻译后修饰 | Phosphoprotein |
检测图片 (3) Click the Picture to Zoom In
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ARG43950 anti-PPP1R15B antibody ICC/IF image
Immunofluorescence: Hela cells stained with ARG43950 anti-PPP1R15B antibody at 5 μg/ml dilution.
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ARG43950 anti-PPP1R15B antibody WB image
Western blot: 293T, Hela and MCF-7 stained with ARG43950 anti-PPP1R15B antibody at 0.5 μg/mL dilution.
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ARG43950 anti-PPP1R15B antibody FACS image
Flow Cytometry: MCF-7 cells stained with ARG43950 anti-PPP1R15B antibody (blue) at 1 μg/1x10^6 cells dilution.
