概述

产品描述	Rabbit Polyclonal antibody recognizes PPM1D
反应物种	Hu
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	PPM1D
抗原物种	Human
抗原	KLH-conjugated synthetic peptide corresponding to aa. 571-602 (C-terminus) of Human PPM1D.
偶联标记	Un-conjugated
別名	WIP1; PP2C-DELTA; Protein phosphatase magnesium-dependent 1 delta; EC 3.1.3.16; Protein phosphatase 1D; p53-induced protein phosphatase 1; PP2C-delta; Protein phosphatase 2C isoform delta

应用说明

应用建议	应用 推荐稀释比 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	293

属性

形式	Liquid
纯化	Purification with Protein G.
缓冲液	PBS and 0.09% (W/V) Sodium azide
抗菌剂	0.09% (W/V) Sodium azide
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 8493 Human PPM1D Swiss-port # O15297 Human Protein phosphatase 1D
基因名称	PPM1D
全名	protein phosphatase, Mg2+/Mn2+ dependent, 1D
背景介绍	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]
生物功能	Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. [UniProt]
研究领域	Cancer antibody; Signaling Transduction antibody
预测分子量	67 kDa

检测图片 (1) Click the Picture to Zoom In