ARG56483
anti-PPAR delta antibody
anti-PPAR delta antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat,Pig,Sheep
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PPAR delta |
|---|---|
| 反应物种 | Hu, Ms, Rat, Pig, Sheep |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PPAR delta |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around aa. 39-54 of Human PPAR delta. |
| 偶联标记 | Un-conjugated |
| 別名 | PPAR-delta; NR1C2; PPAR-beta; PPARB; NUCII; NUCI; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUC1; Peroxisome proliferator-activated receptor delta; FAAR; Peroxisome proliferator-activated receptor beta |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P35396 Mouse Peroxisome proliferator-activated receptor delta Swiss-port # Q03181 Human Peroxisome proliferator-activated receptor delta |
|---|---|
| 基因名称 | PPARD |
| 全名 | peroxisome proliferator-activated receptor delta |
| 背景介绍 | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010] |
| 生物功能 | Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. [UniProt] |
| 预测分子量 | 50 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG56483 anti-PPAR delta antibody WB image
Western blot: 1) 30 µg of Human cerebral cortex, and 2) 30 µg of Mouse liver stained with ARG56483 anti-PPAR delta antibody.
