ARG45951
anti-POLG2 antibody
anti-POLG2 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes POLG2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | POLG2 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein containing to human POLG2. |
| 偶联标记 | Un-conjugated |
| 別名 | DNA Polymerase Gamma 2, Accessory Subunit; POLG2; MTPOLB; DNA polymerase subunit gamma-2, mitochondrial; DNA polymerase gamma accessory 55 kDa subunit; p55; Mitochondrial DNA polymerase accessory subunit; MtPolB; PolG-beta |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 实际分子量 | 55 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -22°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9UHN1 Human DNA polymerase subunit gamma-2, mitochondrial |
|---|---|
| 基因名称 | POLG2 |
| 全名 | DNA Polymerase Gamma 2, Accessory Subunit |
| 背景介绍 | This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions. [provided by RefSeq, Jul 2008] |
| 生物功能 | Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA. [UniProt] |
| 细胞定位 | Mitochondrion. [UniProt] |
| 预测分子量 | 55 kDa |
| 翻译后修饰 | Phosphoprotein. [UniProt]. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45951 anti-POLG2 antibody WB image
Western blot: HepG2 stained with ARG45951 anti-POLG2 antibody at 0.5 μg/ml dilution.
