ARG56526
anti-PNPLA2 / ATGL antibody
anti-PNPLA2 / ATGL antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PNPLA2 / ATGL |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PNPLA2 / ATGL |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around aa. 382-400 of Human Adipose Triglyceride Lipase (ATGL). (KRKLGRHLPSRLPEQVELR) |
| 偶联标记 | Un-conjugated |
| 別名 | Transport-secretion protein 2; Pigment epithelium-derived factor; TTS2.2; FP17548; 1110001C14Rik; TTS2; PEDF-R; IPLA2-zeta; ATGL; Calcium-independent phospholipase A2; TTS-2.2; Patatin-like phospholipase domain-containing protein 2; iPLA2zeta; Desnutrin; Adipose triglyceride lipase; EC 3.1.1.3 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | TBS (pH 7.4) |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PNPLA2 |
| 全名 | patatin-like phospholipase domain containing 2 |
| 背景介绍 | This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010] |
| 生物功能 | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. [UniProt] |
| 预测分子量 | 55 kDa |
| 翻译后修饰 | Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity (By similarity). Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation. |
检测图片 (1) Click the Picture to Zoom In
-
ARG56526 anti-PNPLA2 / ATGL antibody WB image
Western blot: 1) 50 µg of Human liver microsome, 2) 50 µg of HepG2 cell lysate, 3) 50 µg of Rat brown fat homogenate, and 4) 50 µg of Mouse liver 100,000 x g pellet stained with ARG56526 anti-PNPLA2 / ATGL antibody.
