ARG51819
anti-PLC gamma 2 phospho (Tyr1217) antibody
anti-PLC gamma 2 phospho (Tyr1217) antibody for IHC-Formalin-fixed paraffin-embedded sections and Human,Mouse,Rat
Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes PLC gamma 2 phospho (Tyr1217) |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | PLC gamma 2 |
| 抗原物种 | Human |
| 抗原 | Peptide sequence around phosphorylation site of tyrosine 1217 (F-L-Y(p)-D-T) derived from Human PLCγ2. |
| 偶联标记 | Un-conjugated |
| 別名 | Phospholipase C-gamma-2; PLC-IV; Phosphoinositide phospholipase C-gamma-2; PLC-gamma-2; Phospholipase C-IV; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; FCAS3; APLAID; EC 3.1.4.11 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Antibodies were produced by immunizing rabbits with KLH-conjugated synthetic phosphopeptide. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. In addition, non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 缓冲液 | PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | PLCG2 |
| 全名 | phospholipase C, gamma 2 (phosphatidylinositol-specific) |
| 背景介绍 | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. |
| 生物功能 | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling. [UniProt] |
| 研究领域 | Signaling Transduction antibody |
| 预测分子量 | 148 kDa |
| 翻译后修饰 | Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity. |
检测图片 (1) Click the Picture to Zoom In
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ARG51819 anti-PLC gamma 2 phospho (Tyr1217) antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast carcinoma tissue stained with ARG51819 anti-PLC gamma 2 phospho (Tyr1217) antibody (left) or the same antibody preincubated with blocking peptide (right).
